This PhD study aims to investigate different psychological and physiological measures that might predict which patients will develop depression after a diagnosis of cancer. Even though cancer is considered to be a great stressor only a minority of people develop depression. Nevertheless, for those that do there is evidence to suggest that it has a marked impact on their prognosis. With this in mind, this study aims to find out what factors can be used to predict those that will develop depression so as to proactively detect and treat those patients and therefore prevent the depression impacting on their cancer treatment. Investigating Head and Neck and Gastrointestinal cancer should allow us to compare the impact of facial surgery and other treatments on quality of life and mood with another type of cancer. The study is a longitudinal study which follows patients for at least 6 months.